NAIP inflammasomes give the NOD to bacterial ligands
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چکیده
منابع مشابه
Down with doublespeak: NAIP/NLRC4 inflammasomes get specific
The NAIP family members are cytosolic pattern recognition receptors that detect the activity of bacterial type III secretion systems (T3SSs) when they aberrantly translocate one of three NAIP ligands. Mouse NAIP1 and NAIP2 bind the T3SS needle and rod proteins, whereas NAIP5 and NAIP6 bind flagellin. T4SSs are also detected when they cause flagellin to enter the cytosol. Upon interaction with i...
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INSULIN RESISTANCE IS A LEADING CAUSE of type 2 diabetes, and inflammation has emerged as an important mediator between obesity and insulin resistance. The links between immunity and metabolism are extensive and have been proposed to originate from structures in lower organisms that are responsible for both danger and metabolite sensing (6). This has introduced the interesting concept that comm...
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Biochemical studies suggest that the NAIP family of NLR proteins are cytosolic innate receptors that directly recognize bacterial ligands and trigger NLRC4 inflammasome activation. In this study, we generated Naip5(-/-), Naip1(-/-), and Naip2(-/-) mice and showed that bone marrow macrophages derived from these knockout mice are specifically deficient in detecting bacterial flagellin, the type I...
متن کاملThe Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors
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متن کاملThe therapeutic potential of modifying inflammasomes and NOD-like receptors.
Inflammasomes are the central processing units (CPUs) responsible for decoding and integrating signals of foreignness, damage, danger, and distress released by pathogens, cells, and tissues. It was initially thought that the inflammasomes participated only in pathogen recognition and in the pathogenesis of a few, rare, hereditary inflammatory disorders. On the contrary, it is now clear that the...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2014
ISSN: 1471-4906
DOI: 10.1016/j.it.2014.10.002